In 356 B.C. Athenean influence over Greece shifted to the northern region of Macedonia. The leadership of king Phillip II and later his son, Alexander the Great the known ancient world was changed forever. By his death in 332 B.C. Alexander controlled much of the known world. This included Greece, the Persian Empire, all of Asia Minor, the Middle East, and parts of India. Alexander died in 332 B.C. before establishing a strong central government for his vast empire.
With Alexander's conquests Greek culture was spread to other parts of the known world. Greek culture was spread throughout the known world. Now a common language and the Greek Pantheon unified this new world.
Alexander's general and regional governors divided the empire into three parts. Ptolomy the governor of Egypt and Palestine founded the Ptolomaic Empire. Seleucus the governor of Babylon gained control of much of the former Persian empire founded the Selucid Empire. Antigonus, controlled Macedonia and Greece. These three parts of Alexander's former empire became the know as the Hellenistic Age.
From 323 to 30 B.C. great strides were made in knowledge, mathematics, applied mechanics,philosophy, and art.The Greek influence dominated the Mediterranea basin, Adratic Sea, the Italian peninsula, and the city of Rome
With Cleopatra's defeat of the last Ptolomaic ruler ruler in 30 B.C. the power of the ancient world an Western Civilization passed from Greece to Rome and the Mediterranean basin.